Since there are relatively few games this weekend, I’ve decided to post xHPI’s predictions for every game. Best Bets are indicated in bold.
| Favorite | Underdog | Spread | xHPI Pick | xHPI vs. Spread |
| West Virginia | at South Florida | 2 | South Florida | South Florida |
| Northern Illinois | Ohio | 3.5 | Northern Illinois | Ohio |
| at Oregon | UCLA | 31 | Oregon | UCLA |
| at Cincinnati | Connecticut | 9 | Cincinnati | Cincinnati |
| at Ptttsburgh | Syracuse | 10 | Pittsburgh | Pittsburgh |
| at Houston | Southern Miss | 13 | Houston | Southern Miss |
| at Kansas State | Iowa State | 10.5 | Kansas State | Kansas State |
| Wyoming | Colorado State | 5.5 | Colorado State | Colorado State |
| at TCU | UNLV | 38.5 | TCU | UNLV |
| at Baylor | Texas | 2.5 | Baylor | Baylor |
| Utah State | at New Mexico St. | 14.5 | Utah State | New Mexico St. |
| Louisiana-Monroe | at Florida Atlantic | 7.5 | La.-Monroe | La.-Monroe |
| at North Texas | Middle Tennessee | 5.5 | North Texas | North Texas |
| at Nevada | Idaho | 19.5 | Nevada | Idaho |
| LSU | Georgia | 13 | LSU | LSU |
| at Arkansas State | Troy | 17 | Arkansas St. | Arkansas St. |
| at Boise State | New Mexico | 48.5 | Boise State | Boise State |
| BYU | at Hawaii | 8 | BYU | Hawaii |
| at Oklahoma St. | Oklahoma | 3.5 | Oklahoma St. | Oklahoma |
| at San Diego St. | Fresno State | 8 | San Diego St. | San Diego St. |
| Wisconsin | Michigan St. | 9.5 | Wisconsin | Michigan State |
| Virginia | Clemson | 6.5 | Virginia Tech | Virginia Tech |